This is my web development toolbox.

I use a MacBook Pro with 8GB RAM, with an external monitor.

And these are the apps I use:

Alfred

• App launcher, file/web searcher, iTunes controller, and so much more!
• For me, it replaced QuickSilver, which had replaced the built-in Spotlight.
• Mapped to Command-Space

Notational Velocity

• Superb note-taking.
• Syncs with Simplenote web version, which syncs with the iPhone/iPad app — notes everywhere!
• Accessed with Command-Shift-V

Dropbox (Referral link)

• Adds a Dropbox folder to your computer that is synced across all devices. Works everywhere (Windows/Mac/Linux/iOS).
• This is a good roundup of Dropbox tips: The Ultimate Dropbox Toolkit & Guide

To Do / Task Management

• For personal tasks, I’m using OmniFocus for Mac and OmniFocus for iPhone.
• For work tasks, I use Things for Mac, and will probably get the iPhone app soon.

TotalFinder

• Adds tabs to the OS X Finder
• Essential to reduce window clutter!

Sublime Text 2

• Supersedes TextMate. Best with Vintage mode.

Vim Browser Extensions

• These extensions provide Vim keybindings for web browsing.
• Super-useful in my quest to never touch my mouse…
• Vimium in Chrome
• Vimperator in Firefox

Photoshop

Firefox with Firebug

• Still the best for development, though Chrome’s dev tools are quite good
• Use mostly Chrome these days.

Google Chrome

• For anything other than development everything. Super fast!

Transmit

• FTP app, can also access S3 buckets. Don’t use FTP much anymore though…

1Password

• Keep all your passwords in one place, and also good for storing software keys, and “wallet backup”

Adium

• IM client, not much to say here

Cloud App

• Best Feature: Auto-uploads screenshots and adds the URL to your clipboard

Hazel

• Helps keep files organized
• Can run rules like “make files in the Downloads folder red that are older than 3 days”

Sequel Pro

• MySQL GUI

Divvy

• Essential window management for large screens

Dotfiles

• https://github.com/nomatteus/dotfiles

And some online services I pay for (some of these are affiliate links):

• Github Codebase  (See this post for why.)
• Linode (VPS)
• Webfaction (Hosting for side projects/staging sites.)
• HTTPme (Reseller hosting for legacy clients)
• Jungle Disk (To back up my work and home computers.)
• Amazon Web Services (S3: Static asset hosting, and backup archival)
• Netflix (Cancelled this for now. I was barley using it, and seldom watch TV/movies these days.)
• Rdio (Great selection of music. I pay for the Unlimited plan, which allows syncing to your mobile. Replaces iTunes except for albums Rdio doesn’t have.)